If your blood sugar levels are becoming more stable and closer to your target range, it indicates that semaglutide is helping you manage your diabetes effectively
Shorter periods may show initial response but do not capture full potential
Commenting on the approval, Mike Doustdar, President and CEO of Novo Nordisk, emphasized that the availability of an oral GLP-1 option represents an important step toward meeting diverse patient needs in obesity care

Mechanisms contributing to muscle loss: Reduced protein synthesis from decreased food intake and insufficient amino acids Metabolic adaptation , where the body downregulates muscle-preserving processes to conserve energy Hormonal shifts affecting testosterone, IGF-1, and growth hormone Reduced activity levels , particularly in early treatment, due to fatigue or nausea The Clinical Evidence The data is clearand concerning: The STEP 1 and SUSTAIN 8 trials showed that 3940% of the weight lost on semaglutide came from lean mass Regenerons COURAGE trial found that 35% of semaglutide-induced weight loss was lean mass A review published in The Lancet Diabetes & Endocrinology confirmed that lean mass loss ranges from 25% to 39% over 3672 weeks The American Diabetes Association states that 1540% of GLP-1-related weight loss can come from lean body mass If you lose 50 pounds on a GLP-1 medication, you could be losing between 12 and 20 pounds of muscle a change with long-term consequences for your health and metabolism

Recognizing the clinical signs of PWS is typically the first step toward a PWS diagnosis and treatment
Optimal timing for cessation of GLP-1 agonist before elective total hip and knee arthroplasty