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Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes

His1 of exendin-4 formed only limited transient interactions with TM5, however more persistent interactions with E364 6.53 in TM6 were evident in the MD simulations (Supplementary Table 3)

Do not exceed four in 24 hours

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The patients in the OFST group had a lower median number of days of antihistamine therapy compared to OG, and the difference was statistically significant ( p = 0.008) [65]