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[34] [35] Bitter oranges (such as the Seville oranges often used in marmalade) can interfere with drugs [38] including etoposide, a chemotherapy drug, some beta blocker drugs used to treat high blood pressure, and cyclosporine, taken by transplant patients to prevent rejection of their new organs

Why this matters for your runway: Traditional animal toxicology is often slow, expensive, and-lets be honest-frequently fails to predict human safety outcomes