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In the landmark STEP 1 trial, participants lost an average of 14.9% of their body weight over 68 weeks

& Flatt, P

FIGURE 2 Berberine increased the expression of GLP-1 and GLP-1R The expression level of GLP-1 in pancreas and intestine was measured by immunohistochemistry

Medicines that mimic or enhance these hormones have become increasingly important in managing type 2 diabetes and, more recently, obesity

It plays a crucial role in regulating blood sugar levels, promoting insulin secretion, and suppressing glucagon release, which in turn reduces blood glucose, he explains

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