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10.3389/fimmu.2018.00673 43

Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine

at 20 C using 0.1 mM IPTG

doi: 10.1038/s41467-020-18751-8 41 GasbjergLSRosenkildeMMMeierJJHolstJJKnopFK

143 exhibits the highest GLP-1 receptor agonist activity, with an EC50 (half-maximal effective concentration) as low as 0.013 nM, demonstrating exceptionally high receptor activation potency