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ATTAIN-1 (NCT05869903) was a Phase III, 72-week, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of orforglipron at various doses to placebo in adults with obesity, or overweight with at least one of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease, who did not have diabetes

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Jo, Y., Lee, P

In overdose, normal pathways for acetaminophen metabolism are saturated

In a meta-analysis that included both human and rodent studies, Mao et al