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Intrigued by the advantages of PROTACs in degrading dysfunctional proteins, herein, we devised an in-situ formed TYR degrader by utilizing the potent catalytic performance of TYR (Fig

D-amino Acid Modification of Tirzepatide D-amino acids are known to improve peptide stability by reducing proteolytic degradation, making them attractive modifications for peptide therapeutics (Molhoek et al

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