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Common gastrointestinal effects (Phase 2 NEJM) Retatrutide GI side effects at 12 mg in the Phase 2 NEJM trial Effect Nausea Rate at 12 mg Up to 25% Effect Diarrhea Rate at 12 mg Up to 23% Effect Vomiting Rate at 12 mg Up to 26% Effect Constipation Rate at 12 mg Up to 16% GI symptoms were most common during dose escalation and were usually mild to moderate

Symes, Recent progress towards the electrosynthesis of ammonia from sustainable resources

(2019) also emphasize the dual nature of beta-glucuronidase

Siwek et al

Many patients report shorter refractory periods and enhanced overall sexual experience

It sits at the investigational end of the peptide spectrum