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In the present investigation, MTX challenge induced ER stress and UPR mainly through the PERK/CHOP pathway, consistent with previous studies on MTX-induced hepatic injury (Schmidt et al., 2022), nephrotoxicity (Song et al., 2021), and cognitive impairment (Lv et al., 2020)

doi: 10.1007/s40620-020-00738-9 119 LeiterLABainSCBhattDLBuseJBMazerCDPratleyREet al