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In pivotal trials for semaglutide (Ozempic, Wegovy), fatigue was reported in roughly 510% of patients across dose levels, with most cases mild to moderate and resolving within weeks

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Therapeutic goals represent the primary consideration: patients requiring substantial HbA1c reduction (for diabetes management) or significant weight loss may benefit from higher maintenance doses, whilst those achieving targets at lower doses may not require further escalation

Pinching the fat layer before inserting the needle can also ensure the injection stays in the subcutaneous tissue