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Chronic stress and inflammatory stimuli promote microglial activation, leading to sustained release of pro-inflammatory cytokines, reactive oxygen and nitrogen species, and excitotoxic mediators that disrupt synaptic function and neuronal integrity (30)
[DOI] [PMC free article] [PubMed] [Google Scholar] 360.OConnell T.D., Berry J.E., Jarvis A.K., Somerman M.J., Simpson R.U
severe impairment, n = 4)
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Journal of Medicinal Chemistry, Aug 12, 2021