The development of high-dose GLP-1 receptor agonists and the dual GLP-1/GIP receptor agonist tirzepatide resulted in increasing numbers of people reaching HbA1c and body weight targets, with up to 62% attaining normoglycemia with 15-mg tirzepatide [27]
Both the nasal spray and sublingual dropper provide identical metabolic benefits through mucosal absorption
Glucagon-like peptide-1 receptor agonists and risk for gastroesophageal reflux disease in patients with type 2 diabetes: a population-based cohort study
Zachary, 1998
Society has long believed that addiction is a moral problem when it is, in fact, a very real disease with biological risk factors like genetics, psychological risk factors like early childhood trauma, and sociological or environmental risk factors like poverty and unemployment, explains Anna Lembke, MD, a professor of psychiatry and addiction medicine at Stanford University and the author of Dopamine Nation: Finding Balance in the Age of Indulgence
This could be due to enhancement of hepatic amino-acid catabolism with hepatic glucagon receptor activation
