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GLP-1s may not only help people by reducing alcohol intake, but also protect the liver from alcohol metabolism-mediated damage, says one coauthor of that study, Wajahat Mehal, MD, who directs the Yale Fatty Liver Disease Program and the Yale Metabolic Health and Weight Loss Program in New Haven, Connecticut

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Importantly, the weight-reducing efficacy appears comparable to that observed in common, polygenic obesity, as preliminarily evidenced by subgroup analyses from large trials such as SURMOUNT-1

The sympathetic nerves release norepinephrine, which activates receptors on adipocytes, leading to the mobilization of stored triglycerides

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