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For giredestrant treatments, 8.05 10 7 cells were passaged on treatment day 3 into fresh 0.6 nM giredestrant, compound and medium were replenished every 34 days, and one set of cells for each replicate was collected on treatment days 10 and 17 (7.00 10 7 to 8.00 10 7 cells per sample)

An AOP maps the causal chain from a molecular initiating event (e.g., GLP-1 receptor activation) through key events at the cellular and tissue level to an adverse (or beneficial) outcome at the organism level

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coli system was tested for its ability to induce GLP-1 secretion in L cells

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Gastritis: Diagnosis and Treatment