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Our study demonstrates that the UPR sensor protein IRE1 is a critical factor in determining cellular sensitivity to ferroptosis through regulating GSH availability (Fig

Milani PG, et al

The model was iteratively trained using the Adam optimizer, with binary cross-entropy as the loss function, an initial learning rate set at 0.01, batch size of 16, and training epochs set to 100

These medications markedly reduce appetite and food intake, with patients commonly reporting early satiety and decreased interest in eating