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Standard semaglutide titration: Weeks 1-4: 0.25 mg weekly Weeks 5-8: 0.5 mg weekly Weeks 9-12: 1.0 mg weekly Week 13+: 1.7 mg or 2.4 mg weekly (target dose) Hashimoto's-adjusted approach: Weeks 1-6: 0.25 mg weekly (extended to allow thyroid monitoring at week 6) Weeks 7-12: 0.5 mg weekly (TSH check before increasing) Weeks 13-16: 1.0 mg weekly Week 17+: Assess whether higher doses are needed The extended timeline allows for thyroid function checks at each step, ensuring levothyroxine doses are adjusted proactively rather than reactively

Unexplained or debilitating fatigue

The RR for the occurrence of respiratory disease in patients receiving Efpeglenatide was 0.76 (95% CI 0.461.24, p = 0.27)

Keeping a fixed weekly routine helps maintain stable drug levels and more predictable results over time

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There are also side effects to taking GLP-1s, most of which are related to gastrointestinal issues