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NICE technology appraisal TA875 (2023) recommends semaglutide 2.4 mg (Wegovy) as an adjunct to a reduced-calorie diet and increased physical activity for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, when initiated within specialist weight management services

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The remaining Glucose-stimulated insulin secretion (GSIS) appears to be enhanced by nutrients, hormones such as CCK, bile acids and endogenous ethanolamides

In contrast, the total plasma T3 levels were not influenced by resmetirom, indicating that resmetirom did not disrupt thyroid hormone homeostasis (Fig