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For UK clinics selling it as a treatment, the MHRA position now creates direct legal exposure [1]

Despite its therapeutic promise, more studies are needed to confirm its efficacy and safety for clinical use

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Not for human or animal use

The driver may be mast-cell-mediated or systemic rather than NF-B-local, and if so, increasing the dose for additional KPV will not address it see the mast-cell note under Phenotype Considerations