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Small-molecule drugs are subject to Abbreviated New Drug Application (ANDA) pathways for generic approval, which require demonstration of bioequivalence but not repeat clinical trials
The dose is increased gradually to reduce side effects: Starting dose: 1.5 mg once daily for one month Escalation: 4 mg, then 9 mg, then 25 mg, with a minimum of one month at each dose level Maintenance dose: 25 mg once daily, the maximum recommended single daily dose
While bacteriostatic water provides a stable environment, some cellular assays are exquisitely sensitive to pH changes
It slows down the emptying of the stomach, making you feel full for longer
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