The scale barely changes
In addition to its effects on insulin, GIP plays a crucial role in fat accumulation by promoting the activity of adipocyte-expressed lipoprotein lipase and promoting bone formation by preventing osteoclast apoptosis, as evidenced by the thinner bone trabeculae seen in mice lacking GIP receptors [20,21,22]
The medications evaluated include widely used drugs such as Ozempic, Wegovy, and Mounjaro, which are prescribed to treat type 2 diabetes and are increasingly used for weight loss
Overall, these results suggested that GLP-1 RA were beneficial to the cardioprotection of people with diabetic HFpEF
References Sabatine MS, Giugliano RP, Wiviott SD, et al
Gene cell count matrices for control and liraglutide-treated samples were independently normalized with LogNormalize, and the top 2000 most variable genes were used to integrate the 2 data sets (37)