Although peak inflammatory cytokine production (e.g., IL-1) may stem from localized MAPK/ERK dysregulation rather than direct endotoxin influx 174 , the cumulative impact of gutliver axis dysfunction in destabilizing cellular homeostasis remains an indispensable driver of the systemic pathogenesis of bovine laminitis
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Males, compared with females, had greater cell proliferation in the DG Males had a greater density of Ki67-ir cells in the DG compared with females, consistent with findings in meadow voles (Galea and McEwen, 1999)
