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15 Deficiencies in ascorbate have been reported in critically ill human patients with HIV infection, myocardial infarction, lymphoma, type II diabetes, sepsis, or renal failure

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doi: 10.1016/j.juro.2008.10.062

Chem Biol 13:965972 Zhang Z, Kodumuru V, Sviridov S et al (2012) Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors

Multiple studies confirm ginger's safety across various concentrations (100, 333, and 2,000 mg/kg) and experimental periods, demonstrating that it is non-toxic even during pregnancy in rats and gynecological procedures, as shown in clinical studies (561)

Topical glutathione (2%) vs topical tranexamic acid (3%) in adult melasma patients