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Three minutes minimum

According to a study in The New England Journal of Medicine in 2015, they were responsible for about 25 percent of all supplement-related emergency-room visits by adults from 2004 to 2013, causing such symptoms as chest pain and a rapid heartbeat

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Anal Biochem 283:146152 Freeman R, Bahshi L, Finder T, Gill R, Willner I (2009) Competitive analysis of saccharides or dopamine by boronic acid-functionalized CdSe-ZnS quantum dots