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Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL

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It may cause nausea, stomach cramps, decreased appetite, flushing, tiredness, yawning, darkened skin, spontaneous erections of the penis, and other side effects

Incidence of injection site reactions is about 4%

A landmark study demonstrated gut microbiome diversity decreased activation across four major immune cell types (CD4+ T cells, CD8+ T cells, B cells, and monocytes), alongside reductions in 19 circulating inflammatory proteins, including IL-6