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Thus, the excess PyroGlu in a septic patient without an enzymatic deficit in the gamma-glutamyl cycle could be associated with GSH depletion, and therefore excessive oxidative stress and its negative consequences

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Together, the peptides provide a dual-component system for investigating signaling interactions related to cytoskeletal regulation and extracellular matrix remodeling in experimental models

Guo X, Song J, Guan T et al (2015) Characterization of recombinant human gastrointestinal glutathione peroxidase mutant produced in Escherichia coli

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Another implication: as effective as these drugs are, they underscore that lifestyle interventions remain essential