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Furthermore, TMAO induces reactive oxygen species (ROS) generation in macrophages, creating a feed-forward loop that amplifies both inflammatory responses and oxidative stress ( 4.2 Impact of TMAO on DCs DCs, as the most potent professional antigen-presenting cells in the body, play a pivotal role in antigen recognition and signal transmission during immune response

Body composition and diet also matter, particularly excess visceral fat, diets high in refined carbohydrates and ultra-processed foods, and low intake of fibre, fruit and vegetables

doi: 10.21926/obm.geriatr.2002123 5 DaviesMJD'AlessioDAFradkinJKernanWNMathieuCMingroneGet al