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Subsequent research work in human subjects may be required to collect additional data on safety, tolerability, pharmacokinetic properties and efficacy in the target group of patients before a compound or drug can be implemented clinically [265, 266]

To view a copy of this license, visit About this article Cite this article Kelly, R.A., Leedale, J., Calleja, D

Many studies have showed that the mitochondria are impaired in autism

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270 Moreover, studies of breast cancer have revealed metabolic heterogeneity within the CSC compartment itself: basal-like breast CSCs often favor enhanced glycolysis (along with lactate production and export), whereas luminal or estrogen receptor-positive CSCs can adopt a more OXPHOS-dependent phenotype, relying on efficient mitochondrial respiration