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16 HOW SUPPLIED/STORAGE AND HANDLING How Supplied Single-patient-use pens (with multiple weekly doses): Injection: clear, colorless solution of 0.68 mg/mL, 1.34 mg/mL or 2.68 mg/mL of semaglutide available in the following packaging configurations: Each OZEMPIC multi-dose pen is for use by a single patient

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To keep semaglutide working the right way, it needs to be stored properly

Whereas, hydrophobic small molecules frequently failed on the road toward clinical use, due to variable and complexed problems including bio-availability, and swift clearance, which in turn because of their physicochemical nature

The understanding that obesity is a polygenic disease is well-established, with leptin (LEP), leptin receptor (LEPR), melanocortin 4 receptor (MC4R), and proopiomelanocortin (POMC) being prominent contributors