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Common adverse effects include bradycardia, gastrointestinal hyperactivity, and fasciculations

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Patients with severe insulin resistance often see faster initial glucose improvements but slower appetite suppression

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"I cannot get my legs out because the skin hangs over my knee so much." While she doesn't regret losing weight for the benefit of her health, Emilly says the loose skin on her thighs "really does get me down" as it makes her feel self-conscious, and the way she looks naked makes her feel like a "catfish"