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It causes signal transduction pathways to be activated by binding with the growth hormone receptor

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showed that metformin treatment increased the production of granzyme B, perforin, and IFN- by CD8 + T cells in vitro and in vivo, which was associated with a decrease in the immunosuppressive activity of MDSCs due to downregulation of CD39 and CD73 [101]

This work is supported by the Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (Grant number: 24HHZYSS00007)

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