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Althubiti, L

Lysosomal hydrolases are synthesized in the endoplasmic reticulum (ER), modified in the Golgi apparatus with mannose 6-phosphate tags, and recognized by mannose 6-P receptor (MPR)

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496 Conditional and neurone specific deletion of GDI1 (CamkII-Cre + -Gdi1 flox/Y model), showed that the down regulation of GDI in neurones in adult forebrain regions was sufficient to recapitulate the learning deficits previously shown in Gdi1 -null mice