Publication and related biases
diabetes-nave patients have no prior activity for metformin, GLP-1s, or other diabetes medicines such as insulins, DPP-4s, SGLT-2s, etc
We dont have a lot of human data with prolonged exposure, other than in the context of hypoglycemia, that people have looked at, he said, so it is not clear what other effects, either beneficial or adverse, the antagonists might have
As a result of the lack of available safety data, some of the GLP-1 acting drugs are not advised for use during pregnancy
it also triggers hormonal changes (independent of GLP-1 drugs) that reset metabolism, reduce appetite, and often lead to the remission of type 2 diabetes
Table of Contents: How long does it take to see results with Semaglutide GLP-1 for weight loss