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It was found that those with a high PRS had a greater risk of having PD than those with low PRS

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Cell Metab (2022) 34(2):256268.e5

Figure 1 Figure 2 3.1 PKM2 and OA An important regulator of glycolysis is pyruvate kinase (PK), which is an important limiting enzyme in glycolysis ( Synovitis (an inflammatory reaction) plays an important role in the pathogenesis of OA, as studies have shown that 89% of patients with OA have periostitis, and many inflammatory mediators can be found in the synovitis and synovial fluid of patients with OA ( Endoplasmic reticulum (ER) stress has been increasingly demonstrated to be a key etiology leading to the development of OA pathology (i.e., increased chondrocyte apoptosis and inflammatory cytokines) and disease progression

(ISBN 978-2-257-20427-1, lire en ligne), p