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For sublingual administration: altered taste, flushing or warmth in face or body, mild headache (typically transient), dizziness or lightheadedness (usually temporary), nausea (generally mild when it occurs)

doi: 10.1016/j.ejps.2016.08.060 17 HogbenCASchankerLSToccoDJBrodieBB

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The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: An open label trial

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Both Wegovy and Zepbound use gradual escalation approaches partly because tolerability matters