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Compared with 5-FU alone, the combination treatment (i.e., 5-FU + RSL3) significantly suppressed tumor regrowth after 5-FU cessation ( Figures 5FH )

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IGF-1 LR3 IGF-1 LR3 is a modified form of insulin-like growth factor-1 with an arginine substitution at position 3 and a 13-amino acid N-terminal extension, designed to have reduced binding to IGF-binding proteins, which increases its free, biologically active fraction and potency