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Identifying kidney disease The Kidney Disease: Improving Global Outcomes (KDIGO) heatmap for CKD is an international classification based on the eGFR category (G1 to G5) and the albuminuria category (A1 to A3) [17]

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The pathogenesis of cerebral circulation disorders caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, impaired neurotransmitter systems, and vascular pathologies that lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia [27]