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Quinolinic acid (quinurenine metabolites) is a precursor of nicotinamide adenine dinucleotide (NAD) that has neurotoxic properties through its binding to the postsynaptic N-methyl-D-aspartate (NMDA) receptor, followed by a sustained influx of Ca2+ leading to increased oxidative and nitrosative stress (197, 198)

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Cell proliferation was also determined by cell counting using a hemocytometer