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Thirty-two male mice were started on a 60% high-fat diet of 5.24 kcal/g at three weeks of age for 19 weeks, followed by a 45% HFD of 4.73 kcal/g for six additional weeks

This finding contrasts with a recent study that proposed higher M2-type macrophage activity in LC (73)

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The trehalose metabolism pathway is a central component of plant salt-stress responses, with trehalose accumulation enhancing tolerance through multiple mechanisms [87]