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The difficulty is explained as follows: after the binding of the neutral substrate to the dicopper center and the subsequent transfer of a proton from the substrate to peroxide, one electron is transferred from the substrate to one of the two copper ions, leading to the formation of CC coupled dimer products, like a tyrosine dimer

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Magnesium : Supports enzymatic reactions and neurological function

Supplements such as NAC, lipoic acid and Pycnogenol are effective in this manner

Vitamin D also suppressed development of pulmonary emphysema, epithelialmesenchymal transition (EMT), and fibrogenesis, all of which are associated with the development of COPD and are exacerbated by toxicant exposure [24, 25]