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It can be high-intensity interval exercise, but walking or biking is okay, too. 5

[116] This natural increase suggests that melatonin plays important physiological roles during pregnancy, including potential effects on fetal development, maternal circadian rhythms, and pregnancy outcomes

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Loading saturates faster (5 to 7 days) at roughly 0.3 g/kg/day for the loading window (about 20 to 25 g for a 70 to 80 kg adult), but is optional and produces no greater long-term benefit

Full Staggered Titration Schedule Recommended staggered co-titration across 24 weeks Phase Tirz initiation Weeks 1-4 Tirzepatide 2.5 mg/week Cagrilintide Not started Notes Confirm tirzepatide GI tolerance first

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