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J Neurochem 152(6):627649 Wang J et al (2006) Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

Phase II neutralizes them by covalently attaching a conjugation group (glucuronic acid, glutathione, sulfate, acetyl, methyl, or amino acid) that increases polarity, reduces reactivity, and enables transport into bile or urine

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In cosmetics, it works purely as a humectant and film-former

A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohns disease