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In order to better characterize the role of endogenous GLP-1 in post-prandial hypoglycemia secondary to fundoplication, the insulin response to a standardized mixed meal in affected children was measured with concomitant administration of exendin-(9-39) or vehicle through a continuous intravenous infusion
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For example, chronic ICV infusion of the GLP-1R antagonist exendin-9 impairs glucose tolerance in rats, supporting a role for CNS GLP-1R signaling in the maintenance of glycemic control (Sandoval et al., 2008
[DOI] [PubMed] [Google Scholar] 56.European Medicines Agency Meeting Highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 2326 October 2023
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