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The report described a 13-year-old boy with a heterozygous LOF MC4R variant (p.Glu61Lys), accompanied by autism spectrum disorder and trypanophobia, who developed obesity at approximately 6 months of age

It seems that there is a relative protective factor in the female gender

This increase reflects a pattern of growing use of newer GLP-1s, such as Ozempic and Mounjaro, while use of older products, such as Byetta (approved in 2005), Victoza (approved in 2010), and Trulicity (approved in 2014), has declined

Personalized Dosing GLP-1 therapy is tailored to each individual

Theres no head-to-head Phase 3 data yet, but the Phase 2 numbers suggest retatrutide takes off more weight at the same total dose

It can be difficult to sort out hyperammonemia-induced seizure versus seizure-induced hyperammonemia