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Persistent vomiting or diarrhoea can lead to dehydration, which in turn may increase the risk of acute kidney injury a class-relevant concern also noted in the Summary of Product Characteristics (SmPC) for approved GLP-1 receptor agonists such as semaglutide

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Therefore, inhibiting URAT1 effectively opens the "floodgates" for uric acid excretion

From a nutritional point of view, a daily intake greater than 1.6 g/kg (weight)/day helps to optimize hypertrophy and the maintenance of muscle mass during weight loss

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