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Skeletal muscle PGC-11 modulates kynurenine metabolism and mediates resilience to stress-induced depression

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10.1155/2015/648108 BioMed Res

Pharmacological upregulation of Hrd1 expression or activity may accelerate the clearance of misfolded proteins, thereby reducing ER stress and preventing cardiomyocyte apoptosis, an approach particularly relevant in diabetic cardiomyopathy

It is characterized by complex symptoms that broadly impact social, emotional, perceptual, and cognitive functioning