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Higher starting weight is often associated with faster early weight loss

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2), as detailed in the subsequent sections

1.5 Clinical Relevance in Modern Metabolic Disease Management The prevalence of metabolic syndrome continues to escalate globally

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Results suggest orforglipron leads to significant weight loss, at an average of 7.5% of body weight over 72 weeks for those on a 6mg dose, which increased to 8.4% with 12mg and 11.2% with 36mg, compared with 2.1% with placebo