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Decreased GSH levels and impaired GSH synthesis and recycling have been observed in aging, suggesting a potential therapeutic target for restoring redox balance and mitigating oxidative damage

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doi: 10.3945/an.116.012716 Pubmed Abstract CrossRef Google Scholar View reference in article 46 ReynoldsEH

Mutations in genes like CHRNA4 (encoding the alpha-4 nicotinic acetylcholine receptor subunit) have been associated with altered cholinergic signaling, potentially contributing to cognitive decline in Alzheimer's disease