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Although FOXO4s specific effects on mitochondria are as direct as the other peptides above, it is known to regulate the expression of genes involved in oxidative stress response and energy metabolism, which can impact mitochondrial function indirectly (Liu, 2019)

18,19 The multifactorial nature of GI diseases, including altered motility, microbial dysbiosis, and visceral hypersensitivity, makes single-target therapies insufficient