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Tirzepatide causes some side effects during the first few weeks and the dose escalation period, such as nausea, vomiting, diarrhea and constipation
Most people start at a low weekly dose and increase gradually
For example, an APOE 4 carrierwhose allele is consistently linked to higher LDL-C and coronary heart disease riskwho also carries the GLP1R rs6923761 A allele, which attenuates GLP-1-mediated glycaemic response, may warrant closer lipid monitoring and earlier adjunctive lipid-lowering therapy when treated with tirzepatide [106,107]
& Salehi, M
It is not always required, but having one on file significantly reduces the risk of a denied FSA or HSA claim for weight loss medications