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Boerleider, R

First, the optimization of the Nrf2 pathway through targeted drug delivery, e.g., lipid nanoparticles (LPNs) loaded with sulforaphane or bardoxolone methyl could enhance endothelial uptake while avoiding systemic side effects (Zhang et al., 2024), and LNPs conjugated to VCAM-1 antibodies for inflamed vasculature targeting (Gu et al., 2025)

This review consolidates recent advancements in understanding how UA exerts neuroprotective effects on neurodegenerative diseases and emphasizes the dual roles of UA in managing oxidative stress and neuroinflammation

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That said, clinical evidence supporting specific dietary eliminations such as gluten or dairy for perioral dermatitis remains limited and mixed as of 2026

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